General Clinical Chemistry Analyzers and Accessories
Abcam UC2288, p21 inhibitor, 5MG
MW 481.8 Da, Purity >98%. Cell-permeable, phenylcyclohexyl-urea based compound that selectively downregulates the expression of p21, independent of p53 expression, at either transcription or post-transcriptional level. Attenuates p21 protein levels with minimal effect on p21 protein stability. Has no significant effect on the activities of Raf kinases, VEGFR2 kinase, or the phosphorylation state of ERK. Effectively inhibits the growth of multiple cancer cell lines (GI₅₀ = ~ 10 μM against NCI60 cell lines).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Dovitinib, class III-V receptor tyrosine kinase inhibitor, 25MG
MW 392.4 Da, Purity >99%. Potent, selective inhibitor of class III-V receptor tyrosine kinases (RTKs). Inhibits FLT3 (IC₅₀ = 1 nM), c-KIT (IC₅₀ = 2 nM), FGFR (IC₅₀ = 8 nM), VEGFR1/2/3 (IC₅₀ values are 10 nM, 13 nM and 8 nM respectively), PDGFRβ (IC₅₀ = 27 nM), and CSF-1R (IC₅₀ = 36 nM). Selectively blocks growth of B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Dienogest
Chemical. CAS 65928-58-7. Formula C20H25NO2. MW 311.42. Synthetic. Dienogest is an agonist of the progesterone receptor PR. It is an orally active synthetic progestogen with approximately 10% of the relative affinity of progesterone. However it shows very potent progestagenic effects in the endometrium with some antiandrogenic activity and without any androgenic, glucocorticoid or mineralocorticoid effects. It has been used alone or in combination as a contraceptive and to treat uterine fibroids. Dienogest inhibits ovulation primarily through peripheral action rather than by central action on gonadotrophin secretion. Unlike other progestogens, except in the case of its strong effects in the uterus, dienogest is said to lack antiestrogenic effects, and does not antagonize the beneficial effects of estradiol, for instance in the metabolic and vascular systems.
AdipoGen 7-Diethylamino-3-MD-propyl-CC
Chemical. CAS 160291-54-3. Formula C21H23N3O5. MW 397.42. Synthetic. Thiol-reactive probe for protein labelling.
Abcam Kifunensine, class I alpha-mannosidase inhibitor, 5MG
MW 232.19 Da. Cell-permeable, potent, selective inhibitor of class I α-mannosidases. (IC₅₀ = 20-50 nM for mung bean α-1,2-mannosidase I). Alkaloid originally isolated from the actinomycete Kitasatosporia kifunense. Used to suppress Endoplasmic Reticulum-Associated Degradation (ERAD) via the inhibition of endoplasmic reticulum-associated mannosidase activity.
The product is subject to the following: Abcam Restricted Use Statement
Anton Paar For combined laser diffraction and dynamic image analysis measurements.Dispersion unit combining laser diffraction with dynamic image analysis.Laser diffraction measurement range from 10 nm to 2500 µm.
LIQUID FLOW IMAGING DISPERSION UNITFor combined laser diffraction and dynamic image analysis measurements.Dispersion unit combining laser diffraction with dynamic image analysis.Laser diffraction measurement range from 10 nm to 2500 µm.Camera detection range from 5 µm to 2500 µm.Integrated ultrasonication to disperse particles in liquid medium.Flexible working volume: 150-600 mL.Automated filling, rinsing, and draining.Minimum requirements to run:- outflow of the liquid (wastewater disposal connection ora tank)Recommended requirements to run:- water supply 0.1 - 3 bar
AdipoGen 3-oxo-C10-DL-HSL
Chemical. CAS 913697-62-8. Formula C14H23NO4. MW 269.3. Synthetic. N-3-Oxodecanoyl-DL-homoserine lactone is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones AHL are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention, and formation of biofilms.
AdipoGen Ibuprofen Impurity K
Chemical. CAS 43153-07-7. Formula C10H10O3. MW 178.18. The metabolite 2RS-2-4-Formylphenylpropionic acid Ibuprofen Impurity K is a degradation product arising from oxidative and thermal treatments of Ibuprofen which is a non-steroidal anti-inflammatory drug NSAID used to relieve pain from various conditions such as headache, dental pain or menstrual cramps. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2. This product can be used as a working standard or secondary analytical reference standard. It can also be used as an organic building block and intermediate for synthesis.
AdipoGen 3-oxo-C14-DL-HSL
Chemical. CAS 503610-29-5. Formula C18H31NO4. MW 325.4. Synthetic. N-3-Oxotetradecanoyl-DL-homoserine lactone is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones AHL are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention, and formation of biofilms. It appears later than shorter acyl chain AHLs in developing biofilms and like other long chain 3-oxo-AHLs, stimulates the production of putisolvin, which in turn inhibits biofilm formation.
Abcam IWP-4, 50MG
MW 496.6 Da, Purity >98%. Potent inhibitor of Wnt pathway regulatory protein porupine (Porcn). Blocks Wnt protein secretion and prevents the canonical and non-canonical signaling pathways. Blocks palmitylation, and subsquent secretion and activity of Wnt. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.
The product is subject to the following: Abcam Restricted Use Statement
Verichem Laboratories MATRIX PLUS CHOLESTEROL KIT
Matrix Plus Cholesterol Reference Kit 5 x 15mL. aEc Liquid standards with bovine protein aEc Remarkable optical clarity aEc Contains esterified and free cholesterol from bovine serum aEc Prepared with a known linear relation aEc For calibration or calibration verification aEc Constant protein content, pH and ionic strength across concentration levels aEc Prepared without surfactants, glycol or azide aEc Stable 21 months from date of manufacture. Please note that this is a cold product and ships on ice packs.
AdipoGen 6 7-Diethoxy-4-methylcoumarin
Chemical. CAS 314744-06-4. Formula C14H16O4. MW 248.27. Synthetic. Fluorogenic dealkylase substrate for the measurement of the cytochrome-mediated monooxygenase or "mixed function" oxidase system.
